眼睛中进化保守的长基因间非编码RNAbepaly买球

The discovery that the mammalian transcriptome encodes thousands of long intergenic bepaly买球non-coding (linc) RNA transcripts,together with recent evidence that lincRNAs can regulate protein-coding genes,增加了细胞转录/翻译调控的复杂性。事实上,现在有几个报告将lincrnas的突变与可遗传的人类疾病联系起来。

在这里,来自克利夫兰诊所的研究人员根据其跨物种的序列保护,在终分化的成人视网膜神经元中鉴定出一个lincrna亚群。几种具有不同视杆/视锥光感受器含量的哺乳动物眼组织的RNA测序鉴定出18个在这些物种中高度保守的lincrna。18例中有16例保存在人视网膜组织中,其中14例也保存在黄斑区。A subset of lincRNAs exhibited restricted tissue expression profiles in mice,在视网膜有优先表达。Mouse models with different populations of retinal cells as well as in situ hybridization provided evidence that these lincRNAs localized to specific retinal compartments,最显著的是光感受器神经元层。计算基因组位点和启动子区域分析为视网膜有丝分裂后神经元中这些保守的lincrna的调控表达提供了基础。This combined approach identified several lincRNAs that could be critical for retinal and visual maintenance in adults.

  • Mustafi D,凯文尼白X迈达特西尔斯,Khalil AM,帕尔泽夫斯基克(2013)眼睛中进化保守的长基因间非编码RNAbepaly买球.嗡嗡猫[Epub ahead of print].[摘要]

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