肾脏和心血管疾病中的长非编码RNA

Transcription of a large part of the human genome results in RNA transcripts that have limited or no protein-coding potential.这些包括长的非编码RNA(lncrnas)。bepaly买球which are defined as being ≥200 nucleotides long.与micrornas不同,which have been extensively studied,对lncrnas的功能作用知之甚少。bepaly买球然而,studies over the past 5 years have shown that bepaly买球lncRNAs interfere with tissue homeostasis and have a role in pathological processes,including in the kidney and heart.微小RNA海绵H19的发育表达,例如,is altered in the kidneys of embryos carried by hyperglycaemic mothers,而lncrna malat1调节高血糖诱导的内皮细胞炎症。其他lncrnas的假定作用已在心力衰竭等疾病中被bepaly买球确定。心脏自噬,高血压,急性肾损伤,肾小球疾病,急性同种异体排斥反应和肾细胞癌。

bepaly买球心脏发育和疾病中的lncRNas

LNCRNA

bepaly买球LncRNAs regulate cardiac development and disease through various mechanisms.心脏发育:BVHTregulates cardiac lineage commitment and cardiac gene expression by altering the expression ofMESP1and the activity of SUZ12.Loss of终止符,,外星人惩罚者results in impaired cardiovascular development.心力衰竭:克里夫作为mir-489的海绵,which protects against heart failure development by targeting MYD88.多药耐药基因下调mir-361,which in turn inhibits pri-miR-484 processing so reduces mitochondrial fission and apoptosis.循环水平MT-LIPCAR预测心肌梗死后的不良心脏重塑。针对心脏应激,BRG1–HDAC–PARP染色质抑制复合物被激活,哪些抑制MHRTT转录,最终导致心力衰竭。微肽MLN直接与SERCA相互作用,thereby inhibiting Ca2 +进入肌浆网,导致运动表现不佳。内皮功能:低氧应激导致MalAT1,促进内皮细胞增殖和迁移,减少凋亡。Endothelial hypoxia also results in increases in the levels ofLICO00 323miR503Hg,通过调节GATA2和sirtuin1的水平来促进血管生成。心肌梗塞:心肌梗塞的表达增加Mirt1miRT2通过影响一组与左心室重构相关的基因来维持心肌梗死时的射血分数。Autophagy:有源电力滤波器抑制mir-188-3p,导致ATG7水平升高,导致自噬和心肌梗死的增加。

Lorenzen JM,T.T.(2016) Long noncoding RNAs in kidney and cardiovascular diseases. 自然综述肾脏病学[印刷前电子版]。[ 摘要]

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